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Home / News / Oncology News

ONCOLOGY NEWSFEED

FDA Approves Selpercatinib for Lung & Thyroid Cancers with RET Mutations or Fusions

May 11, 2020

On May 8, 2020, the U.S. Food and Drug Administration granted accelerated approval to selpercatinib (Retevmo, Eli Lilly and Company) for the following indications:

  • Adult patients with metastatic RET fusion-positive non-small cell lung cancer (NSCLC);
  • Adult and pediatric patients ≥12 years of age with advanced or metastatic RET -mutant medullary thyroid cancer (MTC) who require systemic therapy;
  • Adult and pediatric patients ≥12 years of age with advanced or metastatic RET fusion-positive thyroid cancer who require systemic therapy and who are radioactive iodine-refractory (if radioactive iodine is appropriate).

Read the full FDA announcement here .
Posted 5/11/2020


FDA Approves Capmatinib for Adults with Metastatic NSCLC

May 6, 2020

On May 6, 2020, the U.S. Food and Drug Administration (FDA) granted accelerated approval to capmatinib (Tabrecta, Novartis) for adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have a mutation that leads to mesenchymal-epithelial transition (MET) exon 14 skipping as detected by an FDA-approved test.

On the same day, the FDA also approved the FoundationOne CDx assay (Foundation Medicine, Inc.) as a companion diagnostic for capmatinib. Read FDA announcement .

Posted 5/6/2020


NAM to Host Webinar on Supporting Clinician Well-Being During COVID-19

May 4, 2020

The National Academy of Medicine (NAM) will host a webinar on Supporting Clinician Well-Being During COVID-19 on Thursday, May 7 from 1:00 to 3:30 PM ET. Webinar objectives include:

  • Describing the existing clinician burnout crisis prior to the COVID-19 pandemic and the goals of the Action Collaborative on Clinician Well-Being and Resilience .
  • Identifying the critical needs and priorities to support the well-being of clinicians, including those in training, during the COVID-19 era.
  • Spotlighting programs, resources, and leadership efforts currently underway to address and monitor the acute and long-term mental health and well-being of clinicians on the frontlines of COVID-19.
  • Voicing the need for a coordinated, national strategy to care for the acute and long-term health and well-being of frontline clinicians delivering healthcare during this public health crisis.

Questions for the panelists can be submitted as you register for the event and during the webinar.A recording of this webinar, slides, and transcript will be available after the event. More information and registration here .

Posted 5/4/2020


FDA Issues Emergency Use Authorization for Remdesivir for Severe COVID-19

May 1, 2020

On May 1, 2020, the U.S. Food and Drug Administration (FDA) issued an emergency use authorization for the investigational antiviral drug remdesivir for the treatment of suspected or laboratory-confirmed COVID-19 in adults and children hospitalized with severe disease. While there is limited information known about the safety and effectiveness of using remdesivir to treat people in the hospital with COVID-19, the investigational drug was shown in a clinical trial to shorten the time to recovery in some patients.

The emergency use authorization allows for remdesivir to be distributed in the U.S. and administered intravenously by healthcare providers, as appropriate, to treat suspected or laboratory-confirmed COVID-19 in adults and children hospitalized with severe disease. Severe disease is defined as patients with low blood oxygen levels or needing oxygen therapy or more intensive breathing support such as a mechanical ventilator. Read the full FDA announcement .

Posted 5/1/2020


CMS Issues Sweeping Regulatory Waivers & Changes to Further Expand Telehealth Options

May 1, 2020

On April 30, the Centers for Medicare & Medicaid Services (CMS) issued another round of sweeping regulatory waivers and rule changes aimed at further increasing access to telehealth for Medicare beneficiaries in response to the COVID-19 public health emergency. Among the announced changes, CMS is:

  • Expanding the types of providers able to provide services via telehealth to Medicare beneficiaries to include physical therapists, occupational therapists, and speech language pathologists.
  • Allowing hospitals to bill for telehealth services provided by hospital-based practitioners in Medicare outpatient settings (including when patients are at home when the home is serving as a temporary provider-based department of the hospital). The agency states that this might include counseling, educational, and therapy services.
  • Expanding the types of services reimbursable under Medicare for audio-only telehealth visits to include behavioral health and patient education services, and increasing reimbursement (retroactively to March 1) for audio-only telehealth visits.
  • Waiving the video requirement for telehealth E/M services. These are now added to the list of audio-only telehealth services that are reimbursable visits.
  • Expediting the process for adding new services to the list of those Medicare services that can be provided by telehealth.
  • Permitting rural health clinics and federally qualified health clinics to provide telehealth as a distant site, thus enabling Medicare beneficiaries to receive care from home.

Read the CMS announcement for full details.

Posted 5/1/2020


FDA Approves Daratumumab and Hyaluronidase-fihj for Multiple Myeloma

May 1, 2020

On May 1, 2020, the U.S. Food and Drug Administration (FDA) approved daratumumab and hyaluronidase-fihj (Darzalex Faspro, Janssen Biotech, Inc.) for adult patients with newly diagnosed or relapsed/refractory multiple myeloma. This new product allows for subcutaneous dosing of daratumumab.

Daratumumab and hyaluronidase-fihj is approved for the following indications that intravenous daratumumab had previously received:

  • in combination with bortezomib, melphalan and prednisone in newly diagnosed patients who are ineligible for autologous stem cell transplant,
  • in combination with lenalidomide and dexamethasone in newly diagnosed patients who are ineligible for autologous stem cell transplant and in patients with relapsed or refractory multiple myeloma who have received at least one prior therapy,
  • in combination with bortezomib and dexamethasone in patients who have received at least one prior therapy,
  • as monotherapy, in patients who have received at least three prior lines of therapy including a proteasome inhibitor and an immunomodulatory agent or who are double-refractory to a PI and an immunomodulatory agent.

Read FDA announcement .

Posted 5/1/2020


FDA Approves Niraparib for Frontine Maintenance of Advanced Ovarian Cancer

April 29, 2020

On April 29, 2020, the U.S. Food and Drug Administration approved niraparib (Zejula, GlaxoSmithKline) for the maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to first-line platinum-based chemotherapy. Read the FDA announcement .

Posted 4/29/2020


CMS Re-evaluating Accelerated Payment Program; Halting Advance Payment Program

April 27, 2020

On April 26, the Centers for Medicare & Medicaid Services (CMS) announced that it is reevaluating the amounts that will be paid under its Accelerated Payment Program and suspending its Advance Payment Program to Part B suppliers effective immediately.

CMS states that significant additional funding will continue to be available to hospitals and other healthcare providers through other programs such as the Coronavirus Aid, Relief, and Economic Security (CARES) Act (PL 116-136) and the Paycheck Protection Program and Health Care Enhancement Act (PL 116-139) for healthcare providers. The U.S. Department of Health and Human Services (HHS) is distributing these funds through the Provider Relief Fund , and these payments do not need to be repaid.

View CMS' updated fact sheet on the Accelerated Payment Program and Advance Payment Program here .

Posted 4/27/2020


President Trump Signs $484 Billion Coronavirus Relief Package

April 24, 2020

On Friday, April 24, President Trump signed into law a $484 billion coronavirus relief package. Congress passed the legislation earlier this week. Included in the emergency funding is $75 billion for hospitals and $25 billion for coronavirus testing. Read a summary of the Paycheck Protection and Health Care Enhancement Act (courtesy of the American Medical Association).

Posted 4/24/2020


House Passes Coronavirus Rescue Funding Package Totaling Nearly $500 Billion

April 23, 2020

On Thursday, April 23, the U.S. House of Representatives passed the coronavirus rescue package totaling nearly $500 billion by a vote of 388-5-1. Four conservative Republicans broke with the GOP leadership to vote against the bill, referencing the impact on the federal deficit. The Senate passed the legislation unanimously by voice vote earlier this week.

The legislation would bring an immediate $321 billion in funding for the Paycheck Protection Program, the small business rescue fund that was depleted last week. The rescue package would also provide $75 billion in emergency relief for hospitals, $25 billion to ramp up coronavirus testing, and an additional $60 billion in economic disaster loans for small businesses.

The bill now goes to President Trump, who is expected the sign the legislation into law.

Posted 4/23/2020


CMS Launches COVID-19 Workforce Virtual Toolkit

April 22, 2020

On April 22, the Centers for Medicare & Medicaid Services (CMS) released a new toolkit to help state and local healthcare decision-makers in managing healthcare workforce challenges in response to the COVID-19 emergency. The online toolkit, developed by the Healthcare Resilience Task Force, includes a full suite of available resources to aid in response based on state and local needs. Access the COVID-19 Workforce Virtual Tookit .

Posted 4/22/2020


FDA Approves Sacituzumab Govitecan-hziy in Previously-Treated Metastatic Triple Negative Breast Cancer

April 22, 2020

On April 22, the U.S. Food and Drug Administration (FDA) granted accelerated approval to sacituzumab govitecan-hziy (Trodelvy™) for the treatment of adult patients with metastatic triple-negative breast cancer who have received at least two prior therapies for metastatic disease. Read FDA announcement . Read corporate press release .

Posted 4/22/2020


ONC, CMS to Exercise Enforcement Discretion for Interoperability Requirements

April 22, 2020

The Office of the National Coordinator for Health Information Technology (ONC) announced April 21 that due to the COVID-19 public health emergency, ONC will exercise its discretion in enforcing all new requirements that have compliance dates and time frames until three months after each initial compliance date or timeline identified in the ONC Cures Act Final Rule. Learn more.Cures Final Act Rule Enforcement Discretion Dates & Timeframes . CMS press release . CMS announcement .

Posted 4/22/2020


Senate Passes Emergency Funding Package Aimed for Providers and Small Businesses

April 21, 2020

On Tuesday, April 21, the U.S. Senate passed by voice vote a $484 billion coronavirus relief bill that includes $75 billion for providers. It is anticipated that House members will vote on the legislation on Thursday.

Source: InsideHealthPolicy Posted 4/21/2020


FDA Approves Ibrutinib in Combination with Rituximab for CLL or SLL

April 21, 2020

On April 21, 2020, the U.S. Food and Drug Administration (FDA) expanded the indication of ibrutinib (Imbruvica) to include its combination with rituximab for the initial treatment of adult patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).

This review was conducted under Project Orbis , an initiative of the FDA Oncology Center of Excellence. Read the FDA announcement .

Posted 4/21/2020


CMS Issues Guidance for Some Facilities to Re-Start Non-Essential Services

April 20, 2020

On April 19, the Centers for Medicare & Medicaid Services (CMS) released guidance for facilities in areas with a low, or relatively low and stable incidence of COVID-19, to resume providing non-emergent, non-COVID-19 healthcare services. Many non-essential surgeries and procedures have been curtailed since March 18 when the agency recommended that facilities limit non-essential care to preserve personal protective equipment (PPE) and prepare for potential surge areas.

The CMS guidance references the White House plan for Opening Up America, released on Friday, April 17. The agency's guidance titled, Opening Up America Again, Centers for Medicare & Medicaid Services (CMS) Recommendations Re-opening Facilities to Provide Non-emergent Non-COVID-19 Healthcare: Phase I , notes that "if states or regions have passed the Gating Criteria (symptoms, cases, and hospitals) announced on April 16, 2020, then they may proceed to Phase I." Access the CMS guidance .

Posted 4/20/2020


FDA Approves Pemigatinib for Certain Unresectable Advanced Cholangiocarcinomas

April 20, 2020

On April 17, 2020, the U.S. Food and Drug Administration (FDA) granted accelerated approval to pemigatinib (Pemazyre, Incyte Corporation) for the treatment of adults with previously treated, unresectable locally advanced or metastatic cholangiocarcinoma with a fibroblast growth factor receptor 2 (FGFR2) fusion or other rearrangement as detected by an FDA-approved test.

The FDA also approved the FoundationOne ® CDX (Foundation Medicine, Inc.) as a companion diagnostic for patient selection. Read FDA announcement .

Posted 4/20/2020


FDA Approves Tucatinib in Combination for Advanced HER2-Positive Breast Cancer

April 17, 2020

On April 17, the U.S. Food and Drug Administration (FDA) approved Tukysa (tucatinib) in combination with chemotherapy (trastuzumab and capecitabine) for the treatment of adult patients with advanced forms of HER2-positive breast cancer that can’t be removed with surgery, or has spread to other parts of the body, including the brain, and who have received one or more prior treatments. Read FDA announcement.


Posted 4/17/2020


FDA Approves Eltrombopag 25-mg Powder for Suspension Package Size

April 17, 2020

Novartis Pharmaceuticals Corporation has announced that the US Food and Drug Administration approved Promacta ® (eltrombopag) 25-mg powder for suspension package size on March 23, 2020. Read corporate announcement .


4/17/2020


Trastuzumab-dttb, Biosimilar of Herceptin, Launches on U.S. Market

April 15, 2020

On April 15, Merck announced the U.S. launch of Ontruzant (trastuzumab-dttb), as a biosimilar of the reference biologic medicine Herceptin. Ontruzant is available in both 150 mg single-dose vials and 420 mg multiple-dose vials, according to the company press release.

Read company announcement .

4/15/2020


CMS Issues Guidance on Payer COVID-19 Coverage

April 13, 2020

On April 11, the Centers for Medicare & Medicaid Services (CMS) released guidance for implementation of the requirement for group health plans and group and individual health insurance to cover both COVID-19 diagnostic testing and certain related items and services provided during a medical visit with no cost sharing. This includes urgent care visits, emergency room visits, and in-person or telehealth visits to the doctor’s office that result in an order for or administration of a COVID-19 test. Covered COVID-19 tests include all FDA-authorized COVID-19 diagnostic tests, COVID-19 diagnostic tests that developers request authorization for on an emergency basis, and COVID-19 diagnostic tests developed in and authorized by states.

The guidance also ensures that COVID-19 antibody testing will be covered. When a COVID-19 antibody test becomes widely available, it could become a key element in fighting the pandemic.

Access the guidance .

4/13/2020


ASCO Launches COVID-19 Registry

April 13, 2020

The American Society of Clinical Oncology (ASCO) has announced the launch of the ASCO Survey on COVID-19 in Oncology Registry (ASCO Registry) to help the cancer community learn about the pattern of symptoms and severity of COVID-19 among patients with cancer. The registry will also aim to gain insight into how COVID-19 infections impact the delivery of cancer care and patient outcomes. The registry will collect both baseline and follow-up data throughout the pandemic and into 2021. Learn more .

Posted 4/13/2020


HHS Starts Distribution of $30 Billion in Provider Relief Funds

April 10, 2020

The bipartisan CARES Act, signed into law March 27, provides for $100 billion in relief funds to hospitals and other healthcare providers on the front lines of the coronavirus response. On April 10, the U.S. Department of Health and Human Services (HHS) announced the immediate start to distribution of $30 billion in relief funds to providers. HHS states that eligible providers will begin receiving payment via direct deposit starting April 10, 2020.
Full details including who is eligible, how payment distributions are determined, what to do if you are an eligible provider, and more here .

Posted 4/10/2020


CMS Adds New COVID-19 Workforce Flexibility Waivers

April 10, 2020

On April 9, the Centers for Medicare & Medicaid Services (CMS) temporarily suspended a number of rules so that hospitals, clinics, and other healthcare facilities can boost their frontline medical staffs during the novel Coronavirus (COVID-19) pandemic.

These changes affect doctors, nurses, and other clinicians nationwide, and focus on reducing supervision and certification requirements so that practitioners can be hired quickly and perform work to the fullest extent of their licenses. The new waivers sharply expand the workforce flexibilities CMS announced on March 30.Access CMS fact sheet on detailing Blanket Waivers for Healthcare Providers (includes information on the new waivers and those announced previously ).

Posted 4/10/2020


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