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Home / Education And Resources / Cancer Types / Lung / NSCLC

ADVANCED NSCLC BIOMARKER TESTING

While the evolution of targeted therapies has significantly improved outcomes and quality of life in patients with advanced non-small cell lung cancer (NSCLC), it can be difficult to keep up with recent advances in this field. The Association of Community Cancer Centers (ACCC)—in partnership with the American Society for Clinical Pathology (ASCP)—is committed to ensuring you have the resources, tools, and education you need to optimize the diagnosis, testing, and management of patients with advanced NSCLC, particularly those with ALK mutations.

For more information on this project, please contact the ACCC Provider Education department.

Optimizing Advanced NSCLC Biomarker Testing, Treatment, and Management Virtual Summit

This enduring material was recorded from a half-day, interactive, CME/CMLE-accredited virtual (live) summit to help members of the cancer care team enhance their coordination of patient care and gain deeper scientific knowledge, skills, and competence in biomarker testing practices, treatment selection, and management of adverse events in patients with advanced NSCLC.

Each highly interactive session is presented by an interprofessional faculty team, features rich scenarios and patient cases involving advanced NSCLC, and introduces the patient perspective to address the following topics:

  • Best practices in care coordination and communication to order appropriate, evidence-based biomarker testing for patients with advanced NSCLC
  • Tips and techniques for optimizing specimen/tissue adequacy for advanced NSCLC biomarker testing
  • Selection process for treatment options for ALK-positive advanced NSCLC patients
  • Managing adverse events associated with ALK inhibitors in first- and second-line treatment settings
  • Overcoming systems-level barriers to optimize advanced NSCLC biomarker testing practices (e.g., timing of testing/test results, insurance coverage considerations)
  • Use of multi-panel NGS pathology reports to guide treatment decision-making
  • NCCN testing guidelines related to ALK and ROS1 oncogene drivers

Receive up to 4.5 hours of CME/CMLE credit as you increase your knowledge and competence in the testing, treatment, and management of patients with advanced NSCLC.

View on YouTube

View Handouts

Additional NSCLC Educational Activities

  • Advanced NSCLC Molecular Tumor Board Simulation [click to the tumor board simulation section] 
  • Advanced NSCLC Project ECHO® Videoconference Series [click to the videoconference section]

Educational activities funded by independent educational grants from Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC, and Pfizer, Inc.

Resources

Guidelines

  • NCCN Guidelines: Non-Small Cell Lung Cancer (includes guidelines for healthcare providers and patients as well as additional educational resources)
  • CAP/IASLC/AMP Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment with Targeted Tyrosine Kinase Inhibitors
  • Collection and Handling of Thoracic Small Biopsy and Cytology Specimens for Ancillary Studies: Guideline From the CAP in Collaboration With CHEST, AMP, ASC, ATS, PPS, PSC, SIR, and STR

Biomarker Testing

  • Biomarker Testing for Patients With Advanced NSCLC: Real-World Issues and Tough Choices (ASCO Educational Book)
  • Molecular Diagnostics in Non-Small Cell Lung Carcinoma
  • Current and Future Trends in NSCLC Biomarker Testing: The American Experience
  • Biomarkers for Lung Cancer Screening and Detection
  • Biomarkers in Lung Cancer (first page preview only):

Immunohistochemistry

  • Immunohistochemistry of pulmonary biomarkers: A perspective from members of the Pulmonary Pathology Society
  • Staining performance of ALK and ROS1 immunohistochemistry and influence on interpretation in non-small cell lung cancer
  • Diagnostic and Predictive Immunohistochemistry for Non–Small Cell Lung Carcinomas (abstract only) 
  • IHC versus FISH versus NGS to detect ALK gene rearrangement in NSCLC: all questions answered? (abstract only)

Liquid Biopsy

  • Liquid Biopsy for Advanced Non-Small Cell Lung Cancer (NSCLC): A Statement Paper from the IASLC
  • Liquid biopsy is a valuable tool in the diagnosis and management of lung cancer
  • Traditional diagnostics versus disruptive technology: The role of the pathologist in the era of liquid biopsy

Targeted Therapies

  • NSCLC from Genomics to Therapeutics: A Framework for Community Practice Integration to Arrive at Personalized Therapy Strategies
  • Advances in Treatment of Locally Advanced or Metastatic NSCLC: Targeted Therapyhttps://pubmed.ncbi.nlm.nih.gov/32402358/
  • ALK Inhibitors for NSCLC: A Systematic Review and Network Meta-Analysis
  • ALK Inhibitors in the Treatment of ALK-Positive NSCLC
  • The Safety and Serious Adverse Events of Approved ALK Inhibitors in Malignancies: A Meta-Analysis
  • Consensus Recommendations for Management and Counseling of Adverse Events Associated with Lorlatinib: A Guide for Healthcare Practitioners

Additional NSCLC Resources from the Association of Community Cancer Centers

Additional resources from ASCP