At the University of Arizona Cancer Center, Banner University Medical Center Tucson, a multidisciplinary team of physicians, pharmacy staff, finance specialists, social workers, nursing staff, and information technologists first identified chemotherapy regimens administered in the inpatient setting that could be safely administered in the outpatient setting, and then implemented a transition plan that included provider and patient education. Benefits included reduced inpatient medical resources and chemotherapy costs, decreased inpatient bed stay, lower infection rates, improved quality of life, and decreased overall cost of care—conservatively estimated at almost $6 million.